ADEN patients were more likely to be male (OR = 1.106, 95% CI, 1.076–1.137, p < 0.001), and present with PVD (OR = 1.232, 95% CI, 1.170–1.296, p < 0.001), atrial fibrillation (OR = 1.142, 95% CI, 1.089–1.197, p < 0.001), anxiety (OR = 1.121, 95% CI, 1.069–1.175, p < 0.033), urinary tract infections (UTI) (OR = 1.682, 95% CI, 1.616–1.751, p < 0.001), and take insulin (OR = 1.625, 95% CI, 1.431–1.845, p < 0.001). This evidence concerns the gene INS and Anxiety.