Female patients were more likely to report a medical history that included insomnia, hypertension (HTN), osteoporosis, anxiety, urinary tract infections (UTI), upper respiratory infections (URI), unspecified thyroid disease, insulin use, secondary dementia, cold sores, GI ulceration, lung adenocarcinoma, small cell lung carcinoma, unspecified headaches, congestive heart failure (CHF), and rheumatoid arthritis (p < 0.001). The gene discussed is INS; the disease is osteoporosis.