INS and Headache: Moreover, females were more likely to take insulin (OR = 0.564, 95% CI, 0.470–0.675, p < 0.001), present with cold sores (OR = 0.291, 95% CI, 0.214–0.396, p < 0.001), GI ulceration (OR = 0.196, 95% CI, 0.149–0.258, p < 0.001),lung adenocarcinoma (OR = 0.125, 95% CI, 0.081–0.191, p < 0.001), small cell lung carcinoma (OR = 0.079, 95% CI, 0.043–0.143, p < 0.001), unspecified headaches (OR = 0.190, 95% CI, 0.163–0.220, p < 0.001), and congestive heart failure (OR = 0.864, 95% CI, 0.809–0.923, p < 0.001).