Female ADEN patients were generally older (p < 0.001), and presented with a range of medical histories, including insomnia, hypertension, dyslipidemia, osteoporosis, unspecified cancer, anxiety, urinary tract infections, upper respiratory infections, insulin use, GI ulceration, squamous cell lung carcinoma, unspecified headaches, congestive heart failure, OSA, cutaneous ulcers, chronic obstructive pulmonary disease, rheumatoid arthritis, and Down syndrome (p < 0.001). This evidence concerns the gene INS and congestive heart failure.