Interestingly, motif analysis of public ATAC-seq data (NGDC: CRA002749) from RA patient monocytes showed enrichment of AP-1, NF-κB, C/EBP, and IRF motifs in differential ACR compared to patients with osteoarthritis (OA) (Figure 3E).43 This evidence concerns the gene TRIM63 and rheumatoid arthritis.