Further mechanistic studies confirmed that QUE inhibited the content of Treg cells and the secretion of the immunosuppressive factor IL-10 in 4T1 transplanted tumor mice by inhibiting the IL-6/JAK2/STAT3 signaling pathway; however, it enhanced the cytotoxicity of CD8+T cells and NK cells, promoting anti-cancer immunity in the TME (143). This evidence concerns the gene CD8A and cancer.