In rats treated with CIS+QUE, QUE increased hematopoietic growth factors (GM-CSF, SCF, and IL-9) and simultaneously inhibited hematopoietic inhibitors (TNF-α and TGF-β1), thereby increasing the differentiation of white blood cells, platelets, neutrophils, erythrocytes, and lymphocytes (126). The gene discussed is TNF; the disease is in situ carcinoma.