WWTR1 and cancer: NF2 promotes Hippo signaling by spatially organizing the MST1/MST2–LATS1/LATS2 kinase cascade at the plasma membrane, with loss of NF2 causing hyperactivated YAP/TAZ, a major mechanism by which YAP/TAZ becomes activated in cancer (Hamaratoglu et al. 2006, Yin et al. 2013, Zhang et al. 2010).