Notably, the critical 14–3-3 binding site S89 of TAZ is always retained in all fusion proteins, whereas the analogous S127 site of YAP may be retained (such as YAP::MAMLD1 in ependymoma) or lost (such as YAP::TFE3 in EHE) (Merritt et al. 2021, Pajtler et al. 2015). Here, WWTR1 is linked to ependymoma.