Working in vivo, multiple studies demonstrated that several YAP fusion proteins, such as YAP::FAM118B, YAP::MAML2, YAP::MAMLD1, YAP::SS18, and YAP::TFE3, can induce brain tumors and/or muscle tumors in mice (Hu et al. 2023; Park et al. 2015; Szulzewsky et al. 2020, 2021, 2022; Takadera et al. 2020). The gene discussed is TFE3; the disease is brain neoplasm.