Furthermore, either loss of both LATS1 and LATS2, leading to activation of wild-type YAP/TAZ, or expression of YAP::MAMLD1 or ZFTA::YAP is sufficient to result in ependymomas in mice, suggesting that the presence of YAP::MAMLD1 or ZFTA::YAP or the loss of LATS1 and LATS2 activates YAP/TAZ to drive ependymoma (Hu et al. 2023). The gene discussed is YAP1; the disease is ependymoma.