CHI3L1 and early-onset autosomal dominant Alzheimer disease: Alzheimer's disease pathology has been shown to have considerable immune and inflammatory related components with the activation of astrocytes and microglia.67,68 CHI3L1 and ‘soluble triggering receptor expressed on myeloid cells 2’ (sTREM2) have been suggested as markers of these process,69-71 though sTREM2 was only reported as a DEP in two studies here (Supplementary Table 3).