YWHAQ and familial Alzheimer disease: 14-3-3 proteins are a family of conserved regulatory proteins that bind to phosphoserine-containing proteins and function as hub proteins that facilitate a wide variety of cellular processes, including signal transduction, apoptosis and cell cycle regulation.47 Our analysis suggest 14-3-3 proteins are changed in the early and middle stages of disease in familial Alzheimer's disease and are also found to be altered in brain tissue.