CDC37 and colorectal cancer: For example, compound 6, a celastrol-triazole derivative, significantly promoted apoptosis in MDA-MB-231 breast cancer cells, while FW-04-806 induced dose- and time-dependent apoptosis in HER2-overexpressing breast cancer lines.48,73 Similarly, Pep-5 and TAT-conjugated peptidomimetics were shown to elicit strong apoptotic responses in hepatocellular carcinoma and colorectal cancer models, respectively.62,63 In parallel, many Hsp90–Cdc37 disruptors cause arrest at specific phases of the cell cycle, thereby halting proliferation.