It significantly inhibited A549 lung cancer cell migration and proliferation, induced apoptosis, and arrested cells at S phase.50 Compound 11g, featuring a 5-fluoro (5-F) substituent, demonstrated potent inhibition of the Hsp90-Cdc37 interaction with a submicromolar IC50 of 0.14 μM. This evidence concerns the gene CDC37 and lung carcinoma.