CDC37 and colorectal cancer: In HCT116 colorectal cancer cells, it showed potent antiproliferative effects with an IC50 of 8.99 ± 1.21 μM, and efficacy was confirmed in a xenograft model, demonstrating a correlation between Hsp90–Cdc37 expression and sensitivity to the compound.54 These findings position DDO-5936 as a promising lead for developing functionally specific Hsp90 modulators.54