58 Complementing these synthetics, the macrodiolide elaiophylin was shown to covalently disrupt the same Hsp90–Cdc37 interface, likewise depleting HIF-1α and galectin-3 and inducing K-Ras-selective apoptosis in cancer cells, thereby reinforcing the nanocluster-dependent mechanism of KRAS selectivity.59 This evidence concerns the gene CDC37 and cancer.