Using a kinase pseudosubstrate-based approach, researchers identified TAT-DDO-59120 as a selective peptide inhibitor capable of disrupting the HSP90–CDC37 PPI.63 The peptide was shown to bind directly to HSP90 both intra- and extracellularly, effectively impairing the PPI and demonstrating antiproliferative activity in HCT116 colorectal cancer cells (IC50 = 12.82 μM). This evidence concerns the gene CDC37 and colorectal cancer.