Elevated tear IgE levels in seasonal (SAC), perennial (PAC), and vernal keratoconjunctivitis (VKC) indicate allergic conjunctival reactions, while levels in epidemic keratoconjunctivitis (EKC) and bacterial conjunctivitis (BC) are similar to those in healthy controls (13). The gene discussed is IGHE; the disease is epidemic keratoconjunctivitis.