Additionally, our study also suggested that inflammatory markers such as WBC (OR: 1.073, 95% CI: 1.015–1.131, P = 0.01), Neut (OR: 1.105, 95% CI: 1.041–1.17, P = 0.001), NLR (OR: 1.122, 95% CI: 1.062–1.189, P < 0.001), and ESR (OR: 1.009, 95% CI: 1–1.017, P = 0.03) markedly increased in psoriasis patients developing CVDs compared with those with no CVDs. The gene discussed is ESR1; the disease is psoriasis.