Asiaticoside (ASI) can activate the AMPK/Nrf2 pathway to improve Atg5, HO-1, Beclin1, p-AMPK, and nuclear Nrf2 expressions, inhibiting autophagy and oxidative stress, thereby relieving myocardial damage of DCM (91). This evidence concerns the gene PRKAA2 and familial dilated cardiomyopathy.