In the cellular experiments conducted by Wang et al. (90), the combination of ginsenosides (GN) and metformin (MET) demonstrated enhanced suppression of reactive oxygen species (ROS) overproduction while modulating PINK1/Parkin-mediated mitophagy, ultimately improving cardiomyocyte function and ameliorating diabetic cardiomyopathy (Table 2). This evidence concerns the gene PRKN and diabetic cardiomyopathy.