Resveratrol (RES) prevented cardiac ischemia-reperfusion by inhibiting autophagy through downregulation of P62 and upregulation of LC3-II/LC3-I through the DJ-1/MEKK1/JNK axis and also induced a decrease in cardiac ischemia-reperfusion-stimulated MAPK/MEKK1 and JNK phosphorylation, as well as increased cell viability (99). This evidence concerns the gene SQSTM1 and myocardial ischemia.