PRKAA2 and hydrops fetalis: In Liu's article, it was mentioned that Shenkui Tongxin Granules can modulate the AMPK-mtTFA-PINK1 signaling axis, promote cardiomyocyte mitophagy, enhance mitochondrial biogenesis, alleviate mitochondrial injury, and reduce energy-metabolism disorders, thus alleviating the advancement of HF (109).