A different view is presented by Pinkas-Himel, claiming that reduced adiponectin concentrations only in a group of girls with obesity and PCOS, excludes the involvement of this adipokine in the aetiopathogenesis of PCOS, and that its concentration inversely correlates with BMI and leptin and insulin concentrations (32). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.