(2017) showed that, compared to normal-weight adolescents with PCOS, a group of adolescents with obesity and PCOS had significantly lower levels of SHBG and HDL-C and significantly higher levels of triglycerides, leptin, fasting insulin, LDL-C and free testosterone (13, 18). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.