Researchers have suggested that genetic changes including single nucleotide polymorphisms (SNPs) within ACE2 could either alter the binding affinity to the virus or gene expression levels, thereby influencing an individual’s susceptibility or protection from infection (Martínez-Gómez et al., 2022; Möhlendick et al., 2021; Mahmood et al., 2022; Liu et al., 2016). This evidence concerns the gene ACE2 and infection.