Among these, endoglin (HHT type 1) on chromosome 9q33-34 and activin receptor-like kinase 1 (ALK1) (HHT type 2) on chromosome 12q13 are the primary pathogenic loci responsible for the majority of HHT cases (Al Tabosh et al., 2024). The gene discussed is ACVRL1; the disease is hereditary hemorrhagic telangiectasia.