The activation of NTSR1 facilitates neuronal excitability and spatial learning and memory (Xiao et al., 2014), and the polymorphism in NTSR1 is associated with the impairment of the working memory function, which is usually affected early during the course of AD (Li et al., 2011; Jahn, 2013). The gene discussed is NTSR1; the disease is Alzheimer disease.