CD4 and neoplasm: Tumor tissues in the CPPM+ group had the lowest percentage of CD3+ CD4+ Foxp3+ T cells (Fig. 5D), and the ratios of CD3+ CD8+ T cells and CD3+ CD4+ T cells to CD3+ CD4+ Foxp3+ T cells were up to 5-fold in the CPPM+ group (Fig. 5E and F).