CD274 and neoplasm: After the medium was treated with IFN-γ, the targeting effect of CPPM on the cell membranes of CT26 and 4T1 was more pronounced as IFN-γ could stimulate to increase the level of PD-L1 expression on the surface of the cancer cells, suggesting that CPPM could target PD-L1 on the membranes of tumor cells (Fig. 3B).