LIMK1 and pancreatic insulinoma: In concurrence, we found decreased phalloidin intensity in rat insulinoma (INS-1) cells overexpressing the Gly511Ala variant, and increased phalloidin intensity in INS-1 cells overexpressing the Ala43Thr variant (Figure 4A) compared to INS-1 cells ectopically expressing WT-LIMK1.