WEE1 and major depressive disorder: Activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) by AMPK activators, such as metformin and resveratrol, has been shown to invoke antidepressant effects in patients with depression (Davinelli et al., 2017; Guo et al., 2014) and in animal models of depression (Ali et al., 2015; Fang et al., 2020; Takahashi et al., 2024a).