TLCL is the predominant CL species in normal heart (Schlame et al., 1993; Sparagna et al., 2007; Shen et al., 2015; Semba et al., 2019) and is significantly reduced in TAZ-deficient cells, BTHS patients, and in TAZ cardiomyocyte-specific knockout mice (Zhu et al., 2021). This evidence concerns the gene TAFAZZIN and Barth syndrome.