In light of the pivotal role of PDH in energy metabolism, as discussed above, it is not surprising that disruption of the PDH-PDP1 axis contributes significantly to metabolic dysregulation, as observed in cancer, neurodegenerative, and other metabolic disorders (Sorbi et al., 1983; Shi et al., 2021; Liang et al., 2024). The gene discussed is PDP1; the disease is metabolic disease.