PDP1 and neoplasm: Studies showing phosphorylation of PDP1 at Tyr-94 in various tumor cells, elevated PDP1 expression resulting in the suppression of AMPK signaling in PDAC, and aberrant expression in colorectal cancer, enhanced inhibition of PDH activity and promoting tumor progression, underscore PDP1 as a key metabolic regulator in cancer, proposing it as a promising target for diagnosis and improved treatment outcomes.