Using genetic tools based on the Dre/Cre dual recombinase system and a fluorescent reporter mouse strain, cell type‐specific p16Ink4a+ senescent cells were traced to reveal mechanisms of macrophages and endothelial cells in liver fibrosis; depletion of senescent macrophages alleviated liver fibrosis, whereas senescent endothelial cells contributed to tissue repair.25 This evidence concerns the gene CDKN2A and Hepatic fibrosis.