demonstrated that EBBP confers cellular protection against lysosomal damage through modulation of selective autophagy.[29] EBBP also enhances cellular stress resistance via activation of the p62‐Nrf2 signaling axis.[45] Furthermore, EBBP inhibited pathological cardiac hypertrophy and ischemia‐reperfusion injury.[31, 32] More importantly, some investigations have identified EBBP as a tumor suppressor in various malignancies.[46, 47] In this regard, we are further convinced that EBBP may play a critical role in regulating of anthracycline‐induced cardiotoxicity. Here, TRIM16 is linked to cardiac hypertrophy.