PRMT4 aggravates DOX‐induced cardiac injury and ferroptosis by inhibiting Nrf2/GPX4 pathway.[17] PGE2/EP1 suppressed DOX‐induced cardiomyopathy through the PKC/Nrf2/SLC7A11 axis.[49] Thus, Nrf2 mitigates DOX‐induced cardiomyopathy by reducing ferroptosis. Here, PRRT2 is linked to cardiomyopathy.