MAP3K1 and neoplasm: MAP3K1 mutations may disrupt cell growth and apoptosis regulation, thereby contributing to tumor progression.39 Alterations in MAP3K1, which promote survival pathways, have been linked to chemoresistance.40MAP3K1 mutations were detected in two out of the 68 samples of colorectal neuroendocrine carcinoma, corresponding to a mutation rate of 2.9%.36