Sensitivity analyses that included time between [11C]UCB‐J PET and CSF collection were also significant (before PVC: R = 0.65, p = 0.007; after PVC: R = 0.56, p = 0.03) and SV2A binding was a significant predictor of CSF SV2A within the AD group (before PVC: η = 0.64, p = 0.002; after PVC: η = 0.55, p = 0.01). Here, SV2A is linked to Alzheimer disease.