We have previously shown that iPan-injection of Wnt+ MSC CdM on day 10 reduced non-fasted hyperglycemia and increased beta cell mass from days 14 to 42 in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice administered 35 mg/kg per day STZ.27 In this study, we assessed for the first time whether iPan-injection of CdM could mediate islet regeneration in immune-competent CK19-CreERT Rosa26-mTomato mice. The gene discussed is KRT19; the disease is severe combined immunodeficiency.