Because the NOD/SCID strain is documented to be sensitive to STZ treatment due to deficiencies in DNA damage response caused by the PrkdcSCID mutation,48 we used dose escalation to determine that CK19-CreERT Rosa26-mTomato mice required 50 mg/kg STZ per day (days 0-4) to consistently induce hyperglycemia by day 10 when MSC-CdM was administered (Supplementary Figure S3A,B). The gene discussed is KRT19; the disease is Hyperglycemia.