Intriguingly, mutations in the homologous region of other actin isoforms, such as skeletal α‐actin (ACTA1), are frequently associated with severe forms of nemaline myopathy, a congenital myopathy characterized by muscle weakness and the presence of nemaline bodies in muscle fibers [45, 46, 47]. Here, ACTA1 is linked to congenital myopathy with cores.