BCL2 and breast cancer: Research indicates that silibinin can reduce the levels of miRNAs (miR-125b, miR-182, and miR-20b), and up-regulate the levels of pro-apoptotic genes (p53, Bax, Caspase-9, PTEN, and Bcl2L11), decrease the level of anti-apoptotic gene (Bcl-2), thereby inducing apoptosis in breast cancer cells (T-47D, MCF-7, and MDA-MB-231) [947, 954].