CDKN1A and liver cancer: For instance, in liver cancer cells (Hep G2 and Huh7), EGCG induces G2/M phase arrest by up-regulating the protein expression of p21 waf1/Cip1 and down-regulating cell cycle-related genes such as CDC25A, CCNB, CCNB2, and CCND [546, 547].