In contrast, icaritin upregulates the protein expression of p21, causing in G0/G1 arrest in liver cancer (Hep G2 and Huh7) cells [731], induces G0/G1 or S phase arrest via regulating cell cycle markers (p27Kip1, p16Ink4a, and pRb) in prostate cancer (PC-3), endometrial carcinoma (RL95-2 and Ishikawa), nasopharyngeal carcinoma (HONE1 and HNE1) and multiple myeloma (U266), liver cancer (PLC/PRF/5) and colon cancer (HT-29) cells [732–734]. Here, CDKN1A is linked to colonic neoplasm.