BAX and familial pancreatic carcinoma: Numerous researches have reported that silibinin can promote the apoptosis by regulating apoptotic-related proteins (e.g., Bax, Bcl-2, and Bcl-xL) and activating Caspases in lung, colon, renal, oral, pancreatic cancers, as well as endometrial carcinoma [920, 921].