Similarly, in breast cancer (MCF-7 and MDA-MB-231) cells, aloe-emodin selectively inhibits proliferation and promotes apoptosis by modulating Bcl-2 protein levels through miR-15a/miR-16–1 upregulation [501], competitively inhibiting telomerase and stabilizing G-quadruplex structure, suppressing hTERT transcription in breast cancer (MDA-MB-453, MDA-MB-231, and MCF-7) cells through E2F1 upregulation and c-Myc downregulation, as well as promoter demethylation [502]. The gene discussed is E2F1; the disease is breast cancer.