Emodin synergistically enhanced the antiproliferative effects of paclitaxel in NSCLC (A549) cells, augmenting apoptosis through up-regulating the protein expression of Bax, Bcl-2, as well as activating the phosphorylation of AKT, and ERK, as well as activating Caspase-3. This evidence concerns the gene BCL2 and non-small cell lung carcinoma.