By targeting key signaling pathways such as IL-6/STAT3, autophagy, glycolysis, and Wnt/β-catenin, as well as by modulating the tumor microenvironment, ginsenosides enhance the efficacy of chemotherapy drugs in cancer types that exhibit resistance, including breast, lung, pancreatic cancers, and glioblastoma. The gene discussed is STAT3; the disease is cancer.