Artemisinin derivatives with piperazine and fluorophore suppresses the cell cycle at the G0/G1 phase, increases Bax expression, decreases Bcl-2 protein expression, induces concentration-dependent apoptosis, and inhibits cell migration via E-cadherin and N-cadherin pathways in colon cancer (HCT 116) cells [181]. This evidence concerns the gene BCL2 and malignant colon neoplasm.