UA inhibits papillary thyroid carcinoma (IHH-4 and TPC-1) cells by classical mechanisms, which inhibits EMT by down-regulating fibronectin-1 (FN1), blocks invasive behaviors of cancer cells, reduces the protein expression of Bcl-2, and activates Caspase-3, which further promotes apoptosis [1065]. The gene discussed is CASP3; the disease is cancer.