JUN and neoplasm: In addition, berberine affected the expression of several proteins important in tumor cell cycle progression, These proteins include Cyclin-D1, Cyclin-B1, Cdc25, CDK1, Epidermal Growth Factor (EGF), Raf/MEK/ERK, and Platelet-derived growth factor (PDGF), activated enhancer-binding protein-1 (AP-1), AP-2, and CD147 [240].