Silibinin inhibits tumor growth through immunomodulatory activities, such as regulating immune cells (Tregs, macrophages, DCs, NK cell), inhibiting inflammatory cytokines (IFN-γ, IL-2, IL-6, IL-10, IL-12, TNF-α, and TGF-β), and modulating immune check points (PD-L1 and PD-1) [889–893]. This evidence concerns the gene IL6 and neoplasm.