DMC induces apoptosis in lung cancer (A549) and bladder cancer (RT4 and TCCSUP) cells by activating Caspase-3 and Caspase-9 activity, and inhibiting the expression of anti-apoptotic proteins (Bcl-2 and Bcl-xL) [402, 403]. The gene discussed is CASP3; the disease is urinary bladder carcinoma.