Triptolide holds promise for reversing drug resistance across cancers, including NSCLC, prostate, and liver cancers, by enhancing chemosensitivity through mechanisms such as down-regulation of P-gp at both mRNA and protein levels, inhibition of the HNF1A/SHH and Keap1/NRF2 pathways [986]. The gene discussed is PGP; the disease is cancer.