PPARGC1A and breast carcinoma: Silibinin also modulates mitochondrial dynamics by up-regulating DRP1, and down-regulating OPA1, MFN1, ATP content, and mitochondrial biogenesis regulatory factors (TFAM, PGC1α, and NRF2), which promotes both extrinsic and intrinsic pathways of apoptosis in breast cancer (MCF-7 and MDA-MB-231) cells [927].