In addition, icaritin upregulates CXC chemokines (e.g., CXCL9 and CXCL10) and T cell marker factors (e.g., CD8 and IFN-γ), facilitating the recruitment of immune cells to tumors, and formed a "hot" tumor microenvironment in lung cancer (Lewis) cells [713]. Here, CD8A is linked to neoplasm.