STAT3 and lung cancer: For instance, transcriptomic analysis have provided a more precise understanding of silibinin's influence on gene expression within various lung cancer (H1650, H1975, A549, H838, and H2030) cells, identifying a connection between silibinin and the modulation of key STAT3 target genes (BIRC5, BRCA1, and FOXM1) that contribute to its anti-cancer effects [958].