Through miR-429, Rg3 regulates genes associated with apoptosis in gastric cancer (AGSR-CDPP) cells resistant to cisplatin [662], regulates cancer cell apoptosis via the MEK signaling pathway in melanoma (A375.S2) cells [663], and promotes p53 demethylation and histone acetylation of p21 and p16 to enhance apoptosis of renal cell carcinoma cells [664]. Here, TP53 is linked to cancer.