Furthermore, UA regulates autophagy by inhibiting mTOR phosphorylation, and acts on 5-FU-resistant human colon cancer (HCT-8/5-FU) cells to induce apoptosis and autophagy, inhibit proliferation, and reverse multidrug resistance in cancer cells, which provides a rationale for colon cancer treatment [1057]. Here, MTOR is linked to malignant colon neoplasm.