Aloe-emodin inhibits nasopharyngeal carcinoma cell (5-8F and CNE1) proliferation, migration, and promotes apoptosis by regulating Dual specificity phosphatase 1 (DUSP1), blocking ERK-1/2, AKT, and p38-MAPK pathways, and stabilizing DUSP1 via ubiquitin–proteasome inhibition [508]. Here, DUSP1 is linked to nasopharyngeal carcinoma.