In addition, UA improves the tumor microenvironment by regulating tumor-associated fibroblasts (CAFs) in the tumor microenvironment, and it inhibits proliferation, migration and invasion of cancer cells by down-regulating the secretion of CXCL12 and decreasing the protein expression of CXCR4 and CXCR7 on the surface of colon cancer (HCT 116 and SW480) cells [1044]. This evidence concerns the gene CXCL12 and neoplasm.