Meanwhile, emodin synergizes with DDP to enhance lung cancer A549/DDP cell apoptosis and impede migration/invasion, likely via inhibiting NF-κB signaling and down-regulating drug resistance proteins (P-gp, MRP, and GST), thereby reversing DDP resistance and augmenting intracellular drug accumulation [483]. The gene discussed is NFKB1; the disease is lung carcinoma.