ULK1 and gastric cancer: Under hypoxic conditions, apigenin treatment in gastric cancer (AGS and SNU-638) cells enhances phosphorylation of ATG5, LC3-II, AMP-activated protein kinase (AMPK), and unc-51 like autophagy activating kinase 1 (ULK1), while simultaneously down-regulating p62, collectively driving autophagy-mediated cell death [71].