DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: Duplication of the Dmd genomic region spanning exons 10 to 17 in the rat causes complete dystrophin deficiency, severe striated muscle dystrophy and premature death, establishing the R-DMDdup10-17 line as a unique mammalian model of a severe, lethal duplication variant in the gene encoding dystrophin.