GABRB3 and Angelman syndrome: Roden, who measured GABRB3 and GABRB2, found the ratio of cortical β3 (GABRB3) to β2 (GABRB2) GABAa subunit expression was reduced in Angelman syndrome compared to controls, driven by increased GABRB2 rather than reduced GABRB3. Looking at the α subunits, Roden et al. found the ratio of α5 to α1 was also reduced in Angelman samples, driven by reduced GABRA5 expression and unchanged GABRA1.