LncRNA KCNQ1OT1 in colorectal cancer cell-derived exosomes can regulate the ubiquitination of PD-L1 through the miR-30a-5p/USP22 pathway, inhibiting the response of CD8+ T cells, allowing CRC cells to evade immune surveillance, thereby promoting the development of CRC [130]. This evidence concerns the gene CD274 and colorectal carcinoma.