For instance, exosomes derived from pancreatic cancer can increase ROS levels through the pro-oxidative factors they carry and activate the STAT3 pathway to promote monocyte survival and arginase expression, exacerbating oxidative stress, inhibiting T cell function, and disrupting antigen presentation capabilities, thereby facilitating the immune evasion and tumor advancement of pancreatic cancer [177]. Here, STAT3 is linked to pancreatic neoplasm.