Notably, in esophageal squamous cell carcinoma (ESCC), TGF-β1-induced LAMC1 expression promotes CXCL1 secretion, which in turn activates the AKT-NFκB signaling axis, leading to the formation of inflammatory CAFs (iCAFs) [30]. The gene discussed is NFKB1; the disease is esophageal squamous cell carcinoma.