Notably, biotin-CIM7 also does not interact with the human lung epithelial BEAS-2B cells (Appendix Fig. S9D), suggesting that CIM7 preferentially interacts with RARα in NSCLC cells over non-tumorigenic cells, consistent with its selective CMA inhibitory activity in NSCLC. The gene discussed is RARA; the disease is non-small cell lung carcinoma.