MAPT and supranuclear palsy, progressive, 1: Of note, the current study emphasizes that [18F]PI-2620 signal increases in PSP vs. HC become larger when using the data-driven temporo-orbital WM reference compared to the conventional cerebellar reference [15, 20, 28, 55] that may be confounded by 4R tau pathology [15, 20, 24, 28, 55].