Exome sequencing followed by Sanger validation in Individual III-2 revealed a de novo pathogenic PTPN11 variant (c.236A>G, p.(Gln79Arg)), consistent with Noonan syndrome, accounting for her history of short stature, pulmonic stenosis, and failure to thrive, but not her CFNS clinical diagnosis (Fig. 1A). This evidence concerns the gene PTPN11 and Pulmonic stenosis.