21amp BP-MPN cells versus controls, as well as in Beat AML top DYRK1A expressors versus bottom, the DREAM DNA repair geneset was downregulated (Fig. 6a–d; normalized enrichment score (NES) −1.74, family-wise error rate (FWER) P value 0.01 for chr. The gene discussed is DYRK1A; the disease is acute myeloid leukemia.