DYRK1A and acute myeloid leukemia: Patients with AML in the top versus bottom quintile of DYRK1A expression (Extended Data Fig. 4d) showed distinct gene expression (Extended Data Fig. 4e), including enrichment for multiple signaling pathways (JAK–STAT, TNF, TGFβ) and downregulation of DNA repair pathways (Extended Data Fig. 4f and Supplementary Table 7).