In gynecological and breast cancers, the pathways mediated by ER, HER2, the Wnt signaling, and also the Notch, Hedgehog, NFκB, and other signaling pathways represent important oncogenic drivers (Feng et al, 2018; Song et al, 2022) (see Fig. 1 for schematic representation of some of these pathways). The gene discussed is ERBB2; the disease is breast cancer.