In gynecological and breast cancers, the pathways mediated by ER, HER2, the Wnt signaling, and also the Notch, Hedgehog, NFκB, and other signaling pathways represent important oncogenic drivers (Feng et al, 2018; Song et al, 2022) (see Fig. 1 for schematic representation of some of these pathways). This evidence concerns the gene ESR1 and breast cancer.