To evaluate whether the increased expression of UHRF1 was associated with the progression of interstitial fibrosis, we first analyzed the correlation between UHRF1 mRNA expression and estimated glomerular filtration rate (eGFR), ACTA2(encoding α-SMA) mRNA expression, and FN1(encoding Fibronectin) mRNA expression in diabetic nephropathy (DN) and focal segmental glomerulosclerosis (FSGS) patients from ERCB Nephrotic Syndrome Tublnt Dataset using Nephroseq V5 online platform. The gene discussed is ACTA1; the disease is focal segmental glomerulosclerosis.