To evaluate whether the increased expression of UHRF1 was associated with the progression of interstitial fibrosis, we first analyzed the correlation between UHRF1 mRNA expression and estimated glomerular filtration rate (eGFR), ACTA2(encoding α-SMA) mRNA expression, and FN1(encoding Fibronectin) mRNA expression in diabetic nephropathy (DN) and focal segmental glomerulosclerosis (FSGS) patients from ERCB Nephrotic Syndrome Tublnt Dataset using Nephroseq V5 online platform. This evidence concerns the gene FN1 and liver dysplastic nodule.