RALGAPB and acute pancreatitis: primary cilia have a known role in organ regeneration as initiating hub for regenerative signaling such as Hedgehog and Notch signaling (Lodh et al, 2014), we suggest that defective primary cilium formation underlies the impaired acinar regeneration capabilities of RalGAPβ- and κB-Ras1/2–deficient mice after acute pancreatitis.