To date, the role of Ral GTPase signaling in the context of pancreatic cancer had only been addressed in tumor cell line studies (Lim et al, 2006) where knockout of RalGAPβ led to enhanced migration and invasion in vitro, enhanced growth upon subcutaneous grafting in vivo, and promotion of primary growth and metastasis when PDAC cells were injected in the spleens of nude mice (Yoshimachi et al, 2021). This evidence concerns the gene RALGAPB and familial pancreatic carcinoma.