KRAS and pancreatic neoplasm: With respect to pancreatic tumor development, we obtained similar results when we knocked down Ral GTPases, RalBP1 or Sec5 in KRasG12D-expressing acini (Figs 5D and S5F–H), highlighting that these Ral-regulated processes are also important in the case of (persistent) ADM initiated by oncogenic KRas mutation.