RALGAPA1 and ciliopathy: Indeed, biallelic variants of RalGAPα1 have been reported in children with neurological deficits, epilepsy, and muscular hypotonia (Wagner et al, 2020), symptoms that are reminiscent of the neurological manifestation of ciliopathies, a group of developmental and degenerative disorders related to primary cilium dysfunction (Hildebrandt et al, 2011).