This includes the elevation 12/15- and 5-LOX derived oxylipins in tissue of colorectal cancer, and the lack of impact of aspirin supplementation (17) (Figs. 2A, 4A and 5G), the increased phosphorylation of β-catenin on Ser-552 in patients with colorectal cancer (reviewed in (76)) and the activation of EP2/EP4 signaling following human helminth infection (reviewed in (77)) (Fig. 6C). This evidence concerns the gene PTGER4 and helminthiasis.