For instance, cathepsin B has been implicated in proteolytic pathways that lead to muscle protein breakdown.[33,34] Li et al showed that cathepsin B is a cysteine protease involved in protein degradation and has emerged as a potential diagnostic marker for skeletal muscle insulin resistance in type 2 diabetes, with its expression inversely correlated with insulin resistance markers in human skeletal muscle cells.[35] These observations align with our findings, suggesting that cathepsin B is detrimental. The gene discussed is CTSB; the disease is type 2 diabetes mellitus.