The involvement of cathepsin S in the inflammatory processes may contribute to muscle weakness by exacerbating muscle inflammation and damage.[36] Supporting this, Wan et al demonstrated that cathepsin S contributed to chronic stress-induced skeletal muscle atrophy and dysfunction by disrupting protein metabolism and promoting apoptosis, suggesting cathepsin S inhibition as a potential therapeutic strategy for stress-related muscle diseases.[10] Further investigation into the role of inflammation in sarcopenia and its impact on muscle strength is warranted. Here, CTSS is linked to sarcopenia.