FcγR-IgG complexes bound to cartilage, specifically targeting collagen type II (CII) or cartilage oligomeric matrix protein, elicit mechanical hypersensitivity in mice, thereby exacerbating joint inflammation and destruction.[35] Advances in our understanding of FcγR biology have opened new avenues for therapeutic interventions, promising to enhance the efficacy of existing treatments and develop novel strategies for managing infectious diseases and cancers. The gene discussed is COMP; the disease is cancer.