CTLA4 and melanoma: Furthermore, articles with more than 1000 citations also included “Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses” (citations = 1105),[21] “Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma” (citations = 1094)[22] and “Signaling in Innate Immunity and Inflammation” (citations = 1067).[23]