NT-proBNP has been widely used as a prognostic marker in heart failure and CAD, reflecting myocardial stress and neurohormonal activation.[31] The lack of statistical significance in our study could be attributed to the relatively low levels of NT-proBNP and BNP observed in our cohort, with most patients maintaining levels within normal or near-normal ranges. The gene discussed is NPPB; the disease is heart failure.