Elevated interleukin-6 levels (OR = 3.051, 95% confidence interval: 1.164–7.999, P = .023) and triglycerides (approaching significance, odds ratio = 1.126, 95% confidence interval: 0.980–1.293, P = .093) were identified as key predictors of CAD progression. This evidence concerns the gene IL6 and coronary artery disorder.