In Shafana et al’s study, CCL8 has been highlighted as a tumor suppressor gene alongside TAGLN2 and CCND2.[34] The capacity of CCL8 to influence immune cell recruitment and cancer cell behaviors underlines its critical role in the disease’s pathogenesis.[33,34] Our findings highlight the chemokine’s potential as a biomarker for early detection and a target for novel treatment strategies. This evidence concerns the gene TAGLN2 and cancer.