CCL25 and neoplasm: Furthermore, CCL25 has been demonstrated to promote tumor cell proliferation and facilitate metastasis by enhancing the migratory and invasive potential of cancer cells toward CCL25 gradients.[35,37,38] This pro-metastatic role of CCL25, documented in cancers such as melanoma and hepatocellular carcinoma, supports the notion that CCL25 could contribute to oral cancer progression through similar mechanisms.