The role of MCP-2, also known as CCL8 alongside other chemokines like CCL2 and CCL7, in recruiting immune cells to the tumor microenvironment and influencing cancer cell proliferation and metastasis, offers a nuanced understanding of oral cancer’s pathogenesis.[33] Our study unveils the significant role of CCL8 in the progression of oral cancer with a direct correlation established between CCL8 levels and oral cancer risk (OR = 1.164, 95% CI 1.001–1.353, P = .048). Here, CCL8 is linked to lip and oral cavity carcinoma.