Furthermore, CCL25 has been demonstrated to promote tumor cell proliferation and facilitate metastasis by enhancing the migratory and invasive potential of cancer cells toward CCL25 gradients.[35,37,38] This pro-metastatic role of CCL25, documented in cancers such as melanoma and hepatocellular carcinoma, supports the notion that CCL25 could contribute to oral cancer progression through similar mechanisms. This evidence concerns the gene CCL25 and lip and oral cavity carcinoma.