Patients with oral cancer exhibit a distinctive cytokine profile, characterized by the elevated expression of cytokines including IL-6, IL-10, TNFα, C-X-C motif chemokine ligand 9 (CXCL9), and monocyte chemoattractant protein 1 (MCP-1), as evidenced in studies.[3,4] This cytokine signature mirrors patterns observed in peripheral blood and plays a crucial role in the tumor microenvironment. This evidence concerns the gene CCL2 and lip and oral cavity carcinoma.