NT-proBNP, as a marker of cardiac dysfunction, reflects the degree of cardiac damage and is closely related to patient prognosis.[19,20] Alataby et al[21] through their research, found that elevated levels of serum lactate, cardiac troponin, and NT-proBNP are independent predictors of mortality in patients with sepsis and septic shock when assessing prognosis. This evidence concerns the gene NPPB and Sepsis.