CD8A and breast cancer: These cytokines inhibit the activation and function of effector T cells, thereby helping tumor cells evade immune surveillance.[51] Our study demonstrated that CD20+ B cells and CD8+ T cells play protective roles in BC, including CD20 on IgD− CD24− B cells, CD20 on transitional B cells, and HLA-DR+ CD8+ T cells, whereas other B-cell subsets, such as naive-mature B cells and IgD− CD38dim B cells, were associated with increased BC risk.