In turn, helper T cells also induce B cells to differentiate into PCs and produce antibodies in response to antitumor responses.[58] Activated memory B cells can lose IgD expression, and CD24− B cells may represent a mature or activated B-cell subset.[59] Thus, among CD20 on IgD− CD24− B cells, which tend to be predominantly memory or activated mature B cells, they are likely to influence B cell activation and proliferation by modulating transmembrane calcium conductance, thereby reducing the risk of BC. This evidence concerns the gene CD24 and breast cancer.