Elevated serum copper and zinc levels have been implicated in BC progression, with copper promoting angiogenesis, a key factor in tumor growth.[12] In addition, elevated levels of C-reactive protein (CRP), an inflammatory marker, are associated with bladder tumor progression.[13] Moreover, significant alterations in glycosylation patterns have been observed in BC cells, including increased glycoprotein expression and structural modifications such as abnormal sialylation and fucosylation.[14] These changes are closely linked to tumor cell proliferation, invasion and metastasis. This evidence concerns the gene CRP and urinary bladder neoplasm.