Nara et al reported that SCC and G-CSF values changed in parallel.[12] However, in the present case, the SCC value was already high before resection, and when the serum G-CSF increased, the CA19-9 value increased much more noticeably than the SCC value possibly due to a change in the characteristics of the tumor after its transformation into a G-CSF-producing lesion. This evidence concerns the gene CSF3 and neoplasm.