Studies have shown that ginsenoside Rg2 can alleviate myocardial fibrosis by inhibiting TGF-β1/Smad signaling.[23] In a mouse model of pressure overload, cryptotanshinone was shown to improve cardiac remodeling by inhibiting the STAT3 and TGF-β/SMAD3 signaling pathways.[48] Icariin enhances cardiac remodeling by modulating the TGF-β1/Smad signaling pathway.[55] Aloesin reduces isoproterenol-induced cardiomyocyte hypertrophy and fibrosis, protecting against cardiac remodeling by inhibiting the TGF-β/pSmad2/3 pathway.[61]. The gene discussed is TGFB1; the disease is Myocardial fibrosis.