This treatment strategy results in the improvement of cardiac remodeling in rat models of heart failure.[63] The optimized Xin Sheng Mai San formulation has also demonstrated potential in alleviating myocardial injury in heart failure rat models by inhibiting the MAPK signaling pathway.[64] The traditional Chinese herbal formula Yi Qi Wen Yang Tang was shown to inhibit hypertrophic remodeling due to TAC through suppressing GATA4 and MAPK phosphorylation. This evidence concerns the gene GATA4 and heart failure.