IFNA1 and cancer: In particular, the values of pM,I (monocyte recruitment by infected cells; Fig 5C) and ∈F,I (cell-related half-maximal inhibitory (IC50) concentration of IFN on the virus production; Fig 5D) were elevated only in the cancer and immunosuppressed virtual patients with severe COVID-19 (p < 0.05); differences between mild and severe virtual patients in the reference VPC were not observed.