IL4R and paracoccidioidomycosis: Conversely, a beneficial role of early IL-4Rα signaling was found in pulmonary cryptococcosis [56]; increases of the Th1 and Th2 cytokines after low-level laser therapy accelerated the healing of the Paracoccidioidomycosis lesions [57]; Th2 and Th17 responses are required for both fungal eradication and prevention of invasion and fungal dissemination in Candida albicans (C. albicans)-induced allergic airway disease [58].