IGF1 and fibrosis: Table 2 lists the top 10 genes (up-regulated and down-regulated) in abscessed livers. Additionally, IPA identified 64 significantly enriched canonical pathways (S3 Table), with 60 activated pathways (Z-scores ≥ 2) and 4 inhibited pathways (Z-scores ≤ −2). Fig 3 shows the result of the selected pathways enriched associated with liver diseases, inflammation, proliferation, and cell death, ECM components, such as hepatic fibrosis signaling, extracellular matrix organization, interleukin-10 signaling, IGF-I signaling, NF-κB signaling, among others.