Similarly, the m.16519T > C mutation has been found in glioblastoma, gastric, lung, ovarian, and prostate tumors [31,34–37] and CCA and HCC cell [32], there was a report indicated that the presence of this mitochondrial variant might predispose individuals with knee osteoarthritis to a heightened baseline inflammatory state involving IL6 [38]. The gene discussed is IL6; the disease is cholangiocarcinoma.