Central to this genetic framework are the BRCA1 and BRCA2 genes, in which pathogenic variants significantly increase breast cancer risk [10], and other genes, such as PALB2, TP53, PTEN, CDH1, CHEK2, and ATM, each contributing to the multifaceted nature of breast cancer susceptibility [11,12]. The gene discussed is PALB2; the disease is breast cancer.