Specifically, for the cycling and mixed-cycling groups, the risk of all-cause dementia was lower among those without APOE ε4 (HR, 0.74 [95% CI, 0.63-0.87]) compared with those with APOE ε4 (HR, 0.88 [95% CI, 0.76-1.02]). The gene discussed is APOE; the disease is dementia.